MovDisordV3, Main, Exploration, bibRecord, 000B21

Absent movement-related cortical potentials in children with primary motor stereotypies

Identifieur interne : 000B21 ( Main/Exploration ); précédent : 000B20; suivant : 000B22

Absent movement-related cortical potentials in children with primary motor stereotypies

Auteurs : Elise Houdayer [États-Unis, Italie] ; Jessica Walthall [États-Unis] ; Beth A. Belluscio [États-Unis] ; Sherry Vorbach [États-Unis] ; Harvey S. Singer [États-Unis] ; Mark Hallett [États-Unis]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2013.

RBID : PMC:4028443

English descriptors

KwdEn :
- Adolescent, Case-Control Studies, Cerebral Cortex (physiopathology), Child, Electromyography, Evoked Potentials, Motor (physiology), Female, Fingers (innervation), Functional Laterality (physiology), Humans, Male, Movement (physiology), Stereotypic Movement Disorder (pathology).
MESH :
- innervation : Fingers.
- pathology : Stereotypic Movement Disorder.
- physiology : Evoked Potentials, Motor, Functional Laterality, Movement.
- physiopathology : Cerebral Cortex.
- Adolescent, Case-Control Studies, Child, Electromyography, Female, Humans, Male.

Abstract

Background

The underlying pathophysiologic mechanism for complex motor stereotypies in children is unknown with hypotheses ranging from an arousal to a motor control disorder. Movement-related cortical potentials (MRCPs), representing the activation of cerebral areas involved in the generation of movements, precede and accompany self-initiated voluntary movements. The goal of this study was to compare cerebral activity associated with stereotypies to that seen with voluntary movements in children with primary complex motor stereotypies.

Methods

Electroencephalographic (EEG) activity synchronized with video recording was recorded in 10 children diagnosed with primary motor stereotypies and 7 controls. EEG activity related to stereotypies and self-paced arm movements were analyzed for presence or absence of early or late MRCP, a steep negativity beginning about one second before the onset of a voluntary movement.

Results

Early MRCPs preceded self-paced arm movements in 8 out of 10 children with motor stereotypies and in 6 out of 7 controls. Observed MRCPs did not differ between groups. No MRCP was identified before the appearance of a complex motor stereotypy.

Conclusions

Unlike voluntary movements, stereotypies are not preceded by MRCPs. This indicates that premotor areas are likely not involved in the preparation of these complex movements and suggests that stereotypies are initiated by mechanisms different from voluntary movements. Further studies are required to determine the site of the motor control abnormality within cortico-striatal-thalamo-cortical pathways and to identify whether similar findings would be found in children with secondary stereotypies.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028443

DOI: 10.1002/mds.25753
PubMed: 24259275
PubMed Central: 4028443

Affiliations:

Le document en format XML

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<term>Fingers (innervation)</term>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">The underlying pathophysiologic mechanism for complex motor stereotypies in children is unknown with hypotheses ranging from an arousal to a motor control disorder. Movement-related cortical potentials (MRCPs), representing the activation of cerebral areas involved in the generation of movements, precede and accompany self-initiated voluntary movements. The goal of this study was to compare cerebral activity associated with stereotypies to that seen with voluntary movements in children with primary complex motor stereotypies.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Electroencephalographic (EEG) activity synchronized with video recording was recorded in 10 children diagnosed with primary motor stereotypies and 7 controls. EEG activity related to stereotypies and self-paced arm movements were analyzed for presence or absence of early or late MRCP, a steep negativity beginning about one second before the onset of a voluntary movement.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Early MRCPs preceded self-paced arm movements in 8 out of 10 children with motor stereotypies and in 6 out of 7 controls. Observed MRCPs did not differ between groups. No MRCP was identified before the appearance of a complex motor stereotypy.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">Unlike voluntary movements, stereotypies are not preceded by MRCPs. This indicates that premotor areas are likely not involved in the preparation of these complex movements and suggests that stereotypies are initiated by mechanisms different from voluntary movements. Further studies are required to determine the site of the motor control abnormality within cortico-striatal-thalamo-cortical pathways and to identify whether similar findings would be found in children with secondary stereotypies.</p>
</sec>
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Movement Disorders (revue)

Absent movement-related cortical potentials in children with primary motor stereotypies

Absent movement-related cortical potentials in children with primary motor stereotypies

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Movement Disorders (revue)
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